Final Fantasy VII: Advent Children will take place two years after the original PlayStation Final Fantasy VII game. The world looks to be peaceful, having avoided destruction, but inhabitants have begun suffering a new physical malaise called Seikon-Shoukougun.

Cloud has been living alone up to this point. While Sephiroth was seen in promotional footage at the Tokyo Game Show, it is not known if he has been resurrected or if his appearance was a dramatization from Cloud's past.

Two mysterious characters are seen in Advent Children--one is a gray-haired man in a tight black costume (actually seen fighting duels with Cloud during various promotional events at TGS). Another mysterious character is covered in white linen from head to toe, seen sitting in a wheelchair. No hints have been given as to who this character is.